Top 10 · Monday, 9 November 2026

The synthesis, stabilization, and structural characterization of high-valent copper complexes are critical for understanding biological and chemical oxidation processes and for developing new catalytic transformations. Herein, we report the ambient generation of a novel terminal mononuclear CuIII-N3 complex supported by a dicarboxamide ligand, H2L (H2L = N,N'-(2,6-diisopropylphenyl)-2,6-pyridinedicarboxamide). The electronic and structural features of the terminal azide ligand play a crucial… Read full abstract

The herb Justicia gendarussa, known as gendarussa, has the potential as an antioxidant. A previous study has identified that ethanol extract from J. gendarussa has the highest antioxidant activity. The study profiled the metabolites of n-hexane, ethyl acetate, n-butanol and water fractions of its ethanol extract using ultrahigh performance liquid chromatography-high resolution mass spectrometry (UHPLC-Q-Orbitrap HRMS). The antioxidant capacities of… Read full abstract

While platinum nanocatalysts exhibit outstanding activity for the hydrogen evolution reaction (HER), their high cost and scarcity underscore the need to develop more efficient and sustainable alternatives. This work reports a highly active, stable, and cost-effective electrocatalytic composite for HER consisting of bimetallic Janus dumbbell Ru─Pt nanoparticles deposited on a titanium oxynitride-graphene support (Ru─Pt/TiON─C). Ru─Pt/TiON─C nanocomposite with particularly low metal… Read full abstract

African swine fever (ASF), caused by the African swine fever virus (ASFV), poses a catastrophic threat to global swine production due to the absence of effective vaccines or therapeutics. Targeting the virally encoded RNA polymerase (RNAP), which is essential for viral transcription, offers a promising antiviral strategy. Capitalizing on our previously resolved high-resolution structure of ASFV RNAP, we conducted a… Read full abstract

Rheumatoid arthritis (RA) is an auto-immune disease that is accompanied by constant inflammation and degradation of joints, causing disabilities and poor quality of life. Even though the available therapies alleviate symptoms, long-term use is often linked with loss of effectiveness, systemic toxicity, and poor patient compliance. Recently, bioactive monomers that can be extracted from Traditional Chinese Medicine (TCM) gained attention… Read full abstract

Quinolines and their derivatives are an important class of N-heterocycles that exhibit a wide range of biological activities. The development of efficient synthetic methodologies for constructing and functionalizing quinoline frameworks has attracted significant attention. Earlier, it was reported that the azine-based NNN(Pd)-pincer complex (C1) can be useful in acceptorless dehydrogenative coupling (ADC) and the borrowing hydrogen process (BHP). In this… Read full abstract

Mössbauer spectroscopy is among the best techniques for probing molecular structures of iron complexes and proteins. Extracting structural insights from experimental spectra often necessitates accurate DFT predictions of isomer shift (IS) and quadrupole splitting (QS) parameters. However, substantial computational cost and sensitivity to the choice of functional and basis set limit their utility for high-throughput structural screening. To address this… Read full abstract

Perovskite materials have been widely applied in various fields owing to their tunable structures, high catalytic efficiency, and stable properties. In recent years, studies have integrated perovskite catalysts with membrane separation processes, enabling simultaneous retention and in situ decomposition of pollutants. This review first summarizes the preparation methods of perovskite catalysts, with a focus on their structural characteristics, electronic modulation… Read full abstract

On-surface synthesized nanographene and aromatic architectures featuring π-radicals have attracted widespread research interest in recent years. However, the role of delocalized π-electrons in governing the reactivity and regioselectivity of radical-involving reactions, such as cyclodehydrogenation, remains underexplored. In this manuscript, we investigated on-surface reactions of tricyclo(dimethoxy-vinyl-phenanthrene) on Au(111). Following multistep demethylation and cyclodehydrogenation, kekulene-hexaone (KeO) has been successfully synthesized. However, systematic… Read full abstract

Two new series of 4-Anilinopyrimidine-N-acylhydrazone derivatives (7a-k and 9a-e) were designed and synthesized as potent dual EGFRWT/VEGFR-2 tyrosine kinase inhibitors. The in vitro antiproliferative activity of the compounds against MDA-MB-231, HepG2 and A549 cancer cell lines revealed derivatives 7e, 7i, 7k, 9a, and 9e were the most active, showing potent cytotoxicity against A549 NSCLC cells with IC50 values in the… Read full abstract